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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DES All Species: 10.91
Human Site: Y122 Identified Species: 30
UniProt: P17661 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P17661 NP_001918.3 470 53536 Y122 L N D R F A N Y I E K V R F L
Chimpanzee Pan troglodytes Q5R1W8 466 53634 L124 Y I D K V R F L E Q Q N K I L
Rhesus Macaque Macaca mulatta XP_001103922 450 51674 E138 V A E L Y E E E L R E L R R Q
Dog Lupus familis XP_535175 466 53579 L124 Y I D K V R F L E Q Q N K I L
Cat Felis silvestris
Mouse Mus musculus P31001 469 53479 Y121 L N D R F A N Y I E K V R F L
Rat Rattus norvegicus P48675 469 53438 Y121 L N D R F A N Y F E K V R F L
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P02542 463 53261 A125 R F L E Q Q N A L M V A E V N
Frog Xenopus laevis P23239 458 52783 N121 V R Y L E Q Q N Q I L V A E V
Zebra Danio Brachydanio rerio Q58EE9 444 51231 Y128 P S R L G D I Y Q E E L R E L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 60.6 95.3 60 N.A. 97.4 97.8 N.A. N.A. 85.9 80.8 55.7 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 77.2 95.5 77.2 N.A. 99.1 98.9 N.A. N.A. 92.5 90.4 74.2 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 13.3 6.6 13.3 N.A. 100 93.3 N.A. N.A. 6.6 6.6 26.6 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 40 46.6 40 N.A. 100 93.3 N.A. N.A. 13.3 20 46.6 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 12 0 0 0 34 0 12 0 0 0 12 12 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 56 0 0 12 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 12 12 12 12 12 12 23 45 23 0 12 23 0 % E
% Phe: 0 12 0 0 34 0 23 0 12 0 0 0 0 34 0 % F
% Gly: 0 0 0 0 12 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 23 0 0 0 0 12 0 23 12 0 0 0 23 0 % I
% Lys: 0 0 0 23 0 0 0 0 0 0 34 0 23 0 0 % K
% Leu: 34 0 12 34 0 0 0 23 23 0 12 23 0 0 67 % L
% Met: 0 0 0 0 0 0 0 0 0 12 0 0 0 0 0 % M
% Asn: 0 34 0 0 0 0 45 12 0 0 0 23 0 0 12 % N
% Pro: 12 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 12 23 12 0 23 23 23 0 0 0 12 % Q
% Arg: 12 12 12 34 0 23 0 0 0 12 0 0 56 12 0 % R
% Ser: 0 12 0 0 0 0 0 0 0 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 23 0 0 0 23 0 0 0 0 0 12 45 0 12 12 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 23 0 12 0 12 0 0 45 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _